The anti-stress supplement Peptidea is a fish protein hydrolysate obtained from deep ocean fish using a cutting-edge enzymatic process.
Made up of 18 amino acids with a molecular weight of less than 1,000 daltons, its peptides act as precursors to regulatory neuropeptides and neurotransmitters of the nervous system, including endorphins, serotonin and melatonin. These play a major role in mood and stress management. Its compounds have also been shown to modulate the concentration of GABA, a neurotransmitter that inhibits excitatory nerve signals emitted, in particular, in situations of anxiety or strong emotion.
How does Peptidea fish protein hydrolysate work in the body?
With its innovative formulation, Peptidea acts at various levels of the nervous system.
First of all, it influences levels of gamma aminobutyric acid (GABA). Discovered by Eugene Roberts and Sam Frankel in the 1950s, this inhibitory neurotransmitter acts to slow down nerve cell activity by binding to specific receptors (called GABAA and GABAB). Highly-abundant in cerebral cortex neurons, it governs behaviour and emotional stability, which appears tested in the event of anger, irritability or aggression (1). It thus counterbalances the excitatory potential of glutamate – from which it is nonetheless made (2).
At the same time, the peptides in Peptidea act as a precursor to several chemical mediators intrinsically linked to well-being:
- endorphins: produced by the hypothalamus and pituitary gland, these neuropeptides have the specific feature of binding to morphine receptors. The best-known of these, beta-endorphin, alters perception of pain and stress (3-4) ;
- serotonin: known as the ‘happy hormone ’, this important neuromediator governs self-control and inhibition (5) ;
- melatonin: synchronised with the day-night cycle, this neurohormone regulates the body’s internal clock. Released by the pineal gland at particular times, its production increases at bedtime, peaking during the night (6).
It’s worth mentioning that, unlike certain allopathic tranquillisers, fish protein hydrolysates do not cause drowsiness or a lack of alertness.
A fish peptide supplement with proven efficacy
The supplement Peptidea has been the subject of various scientific publications to support its mode of action:
- adaptability to stress. In a study on rats, the effects of a standard anxiolytic were compared with those of hydrolysed fish proteins, both at rest and in a situation of acute stress. Levels of adrenaline, noradrenaline, ACTH (adrenocorticotropic hormone) and GABA in the hypothalamus and hippocampus were all measured (7);
- cognitive abilities. Other studies have also looked at the impact of fish protein hydrolysates on cognitive function (learning, memorisation, concentration (8).
Daily serving: 6 capsules
Number of servings per bottle: 15 |
Quantity
per serving |
Peptidyss®
(deep sea fish protein hydrolysate) |
1 200 mg |
Other ingredients: Acacia gum.
Peptidyss® - Abyss Ingredients, France
|
Each vegetarian capsule contains 200 mg of Peptidyss®.
Take between one and six capsules every morning for at least 15 consecutive days.
Warning: Do not take Peptidea if allergic to fish.
- Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci. 2020;14:923. Published 2020 Sep 17. doi:10.3389/fnins.2020.00923
- Jewett BE, Sharma S. Physiology, GABA. [Updated 2021 Jul 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513311/
- Sprouse-Blum AS, Smith G, Sugai D, Parsa FD. Understanding endorphins and their importance in pain management. Hawaii Med J. 2010;69(3):70-71.
- Pilozzi A, Carro C, Huang X. Roles of β-Endorphin in Stress, Behavior, Neu-roinflammation, and Brain Energy Metabolism. Int J Mol Sci. 2020;22(1):338. Published 2020 Dec 30. doi:10.3390/ijms22010338
- Klasen M, Wolf D, Eisner PD, et al. Serotonergic Contributions to Human Brain Aggression Networks. Front Neurosci. 2019;13:42. Published 2019 Feb 22. doi:10.3389/fnins.2019.00042
- Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W, Yu F. A review of sleep disorders and melatonin. Neurol Res. 2017 Jun;39(6):559-565. doi: 10.1080/01616412.2017.1315864. Epub 2017 May 1. PMID: 28460563.
- Bernet F, Montel V, Noël B, Dupouy JP. like effects of a fish protein hydrolysate (Gabolysat PC60) on stress responsiveness of the rat pituitary-adrenal system and sympathoadrenal activity. Psychopharmacology (Berl). 2000 Mar;149(1):34-40. doi: 10.1007/s002139900338. PMID: 10789880.
- Chataigner M, Lucas C, Di Miceli M, et al. Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging. Front Nutr. 2021;8:750292. Published 2021 Nov 23. doi:10.3389/fnut.2021.750292
- McCraty R, Zayas MA. Cardiac coherence, self-regulation, autonomic stability, and psychosocial well-being. Front Psychol. 2014;5:1090. Published 2014 Sep 29. doi:10.3389/fpsyg.2014.01090
- Goldfarb AH, Jamurtas AZ. Beta-endorphin response to exercise. An update. Sports Med. 1997 Jul;24(1):8-16. doi: 10.2165/00007256-199724010-00002. PMID: 9257407.
- Hulsken S, Märtin A, Mohajeri MH, Homberg JR. Food-derived seroto-nergic modulators: effects on mood and cognition. Nutr Res Rev. 2013 Dec;26(2):223-34. doi: 10.1017/S0954422413000164. Epub 2013 Oct 18. PMID: 24134856.
- Nehlig A. The neuroprotective effects of cocoa flavanol and its in-fluence on cognitive performance. Br J Clin Pharmacol. 2013;75(3):716-727. doi:10.1111/j.1365-2125.2012.04378.x
- Dfarhud D, Malmir M, Khanahmadi M. Happiness & Health: The Biolo-gical Factors- Systematic Review Article. Iran J Public Health. 2014;43(11):1468-1477.
- Choi DW, Chun SY, Lee SA, Han KT, Park EC. Association between Sleep Duration and Perceived Stress: Salaried Worker in Circumstances of High Workload. Int J Environ Res Public Health. 2018;15(4):796. Published 2018 Apr 19. doi:10.3390/ijerph15040796
- Hidese S, Ogawa S, Ota M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10):2362. Published 2019 Oct 3. doi:10.3390/nu11102362
- Jamshidi N, Cohen MM. The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evid Based Complement Al-ternat Med. 2017;2017:9217567. doi:10.1155/2017/9217567
- Pickering G, Mazur A, Trousselard M, et al. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. 2020;12(12):3672. Published 2020 Nov 28. doi:10.3390/nu12123672