0
en
US
X
× SuperSmart Learn by health topic New articles Popular articles Visit our shop My account Smart Prescription Blog Loyalty scheme Language: English
Anti-ageing Guides and tutorials

Glycation: the silent process that accelerates ageing

Glycation is a silent but powerful chemical reaction that plays a key role in the aging process. Find out exactly what’s involved in this ‘spontaneous caramelisation’ of the body, and how to curb it.
Woman face aged due to glycation
Protein glycation is known to precipitate ageing.
Rédaction Supersmart.
2020-11-10Comments (0)

What is glycation (or the Maillard reaction)?

Glycation – a simple definition

Glycation, also known as the Maillard reaction, is the binding of sugars to proteins (1). It both occurs spontaneously in the body as well as when we cook certain foods.

This chemical reaction leads to the development of glycated proteins, which accumulate inside cells and cannot be eliminated.

In a matter of days, glycated proteins are converted into compounds called Amadori products (2). After a few weeks, these end up forming Maillard products, or AGEs (Advanced Glycation End Products). Once underway, this last conversion is irreversible (3).

AGEs accelerate ageing

Maillard products are known to promote the development of various problems :

In short, the various stages of glycation together cause an acceleration in ageing (6-7). This process is stimulated by an overload of sugar in the body, and thus has an even more dramatic effect on diabetics (who have elevated levels of glycated haemoglobin) (8-9).

What can you do to fight glycation?

The solution lies primarily in what you eat

If you want to fight this ‘caramelisation’ of your body and slow down the effects of ageing, you need to start by looking at your diet...

Modern diets are often high in sugar and contain too much food cooked at high temperatures, both of which encourage protein glycation (10).

Which foods and cooking methods should you prioritise?

To prevent excessive glycation in your body:

To combat glycation, it’s also important to take regular exercise and to make sure you manage day to day stress effectively (12).

Nutrients known for their anti-glycation effects

The benefits of carnosine, aminoguanidine, Yerba mate...

In recent years, a number of studies have highlighted certain substances with the potential to help inhibit the formation of AGEs (13-14).

They include:

Further scientific research is needed in order to clarify all the mechanisms involved.

A supplement combining all the most effective substances in this field

Certain supplements have been formulated to combine several of these micronutrients. One of the best-known is Anti-Glycation Formula, which amongst other synergistic compounds, contains high levels of carnosine, aminoguanidine, pyridoxamine and mate leaf extract. Why not discover for yourself the benefits of this formulation based on cutting-edge research?

References

  1. Fournet M, Bonté F, Desmoulière A. Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging. Aging Dis. 2018;9(5):880-900. Published 2018 Oct 1. doi:10.14336/AD.2017.1121
  2. Shumilina J, Kusnetsova A, Tsarev A, et al. Glycation of Plant Proteins: Regulatory Roles and Interplay with Sugar Signalling?. Int J Mol Sci. 2019;20(9):2366. Published 2019 May 13. doi:10.3390/ijms20092366
  3. Gkogkolou P, Böhm M. Advanced glycation end products: Key players in skin aging?. Dermatoendocrinol. 2012;4(3):259-270. doi:10.4161/derm.22028
  4. Gill V, Kumar V, Singh K, Kumar A, Kim JJ. Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health. Biomolecules. 2019;9(12):888. Published 2019 Dec 17. doi:10.3390/biom9120888
  5. Fournet M, Bonté F, Desmoulière A. Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging. Aging Dis. 2018;9(5):880-900. Published 2018 Oct 1. doi:10.14336/AD.2017.1121
  6. Gkogkolou P, Böhm M. Advanced glycation end products: Key players in skin aging?. Dermatoendocrinol. 2012;4(3):259-270. doi:10.4161/derm.22028
  7. Chaudhuri J, Bains Y, Guha S, et al. The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality. Cell Metab. 2018;28(3):337-352. doi:10.1016/j.cmet.2018.08.014
  8. Song F, Schmidt AM. Glycation and insulin resistance: novel mechanisms and unique targets?. Arterioscler Thromb Vasc Biol. 2012;32(8):1760-1765. doi:10.1161/ATVBAHA.111.241877
  9. Younus H, Anwar S. Prevention of non-enzymatic glycosylation (glycation): Implication in the treatment of diabetic complication. Int J Health Sci (Qassim). 2016;10(2):261-277.
  10. Uribarri J, Woodruff S, Goodman S, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010;110(6):911-16.e12. doi:10.1016/j.jada.2010.03.018
  11. Uribarri J, Woodruff S, Goodman S, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010;110(6):911-16.e12. doi:10.1016/j.jada.2010.03.018
  12. Kim CS, Park S, Kim J. The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise. J Exerc Nutrition Biochem. 2017;21(3):55-61. doi:10.20463/jenb.2017.0027
  13. Gill V, Kumar V, Singh K, Kumar A, Kim JJ. Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health. Biomolecules. 2019;9(12):888. Published 2019 Dec 17. doi:10.3390/biom9120888
  14. Kim CS, Park S, Kim J. The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise. J Exerc Nutrition Biochem. 2017;21(3):55-61. doi:10.20463/jenb.2017.0027
  15. Ghodsi R, Kheirouri S. Carnosine and advanced glycation end products: a systematic review. Amino Acids. 2018 Sep;50(9):1177-1186. doi: 10.1007/s00726-018-2592-9. Epub 2018 Jun 1. PMID: 29858687.
  16. Younus H, Anwar S. Prevention of non-enzymatic glycosylation (glycation): Implication in the treatment of diabetic complication. Int J Health Sci (Qassim). 2016;10(2):261-277.
  17. Babizhayev MA, Deyev AI, Savel'yeva EL, Lankin VZ, Yegorov YE. Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging. J Dermatolog Treat. 2012 Oct;23(5):345-84. doi: 10.3109/09546634.2010.521812. Epub 2011 Jul 14. PMID: 21756141.
  18. He C, Sabol J, Mitsuhashi T, Vlassara H. Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration. Diabetes. 1999 Jun;48(6):1308-15. doi: 10.2337/diabetes.48.6.1308. PMID: 10342821.
  19. Younus H, Anwar S. Prevention of non-enzymatic glycosylation (glycation): Implication in the treatment of diabetic complication. Int J Health Sci (Qassim). 2016;10(2):261-277.
  20. Thornalley PJ. Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts. Arch Biochem Biophys. 2003 Nov 1;419(1):31-40. doi: 10.1016/j.abb.2003.08.013. PMID: 14568006.
  21. Ramis R, Ortega-Castro J, Caballero C, et al. How Does Pyridoxamine Inhibit the Formation of Advanced Glycation End Products? The Role of Its Primary Antioxidant Activity. Antioxidants (Basel). 2019;8(9):344. Published 2019 Sep 1. doi:10.3390/antiox8090344
  22. Metz TO, Alderson NL, Thorpe SR, Baynes JW. Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications. Arch Biochem Biophys. 2003 Nov 1;419(1):41-9. doi: 10.1016/j.abb.2003.08.021. PMID: 14568007.
  23. Younus H, Anwar S. Prevention of non-enzymatic glycosylation (glycation): Implication in the treatment of diabetic complication. Int J Health Sci (Qassim). 2016;10(2):261-277.
  24. Lunceford N, Gugliucci A. Ilex paraguariensis extracts inhibit AGE formation more efficiently than green tea. Fitoterapia. 2005 Jul;76(5):419-27. doi: 10.1016/j.fitote.2005.03.021. PMID: 15894431.
  25. Bains Y, Gugliucci A. Ilex paraguariensis and its main component chlorogenic acid inhibit fructose formation of advanced glycation endproducts with amino acids at conditions compatible with those in the digestive system. Fitoterapia. 2017 Mar;117:6-10. doi: 10.1016/j.fitote.2016.12.006. Epub 2016 Dec 22. PMID: 28012919.
SharePinterest

Comments

You must be connected to your account to leave a comment
Be the first to review this article
Our selection of articles
Older couple taking dietary supplements
Later life: the best dietary supplements for older people

If you’re over – or fast-approaching – 70 years of age, or want some advice for loved ones in this age group, this article on ‘senior’ supplements is for you.

Basket of foods rich in antioxidant polyphenols
Indispensable: the 12 fruits and vegetables with the highest polyphenol content

The polyphenol content of fruits and vegetables is one of the main reasons these foods are so good for our health. But which contain the most? And can you guess which one takes the no. 1 spot?

Smiling woman with antioxidant foods in her hair
The 7 most powerful antioxidants

Antioxidants have been very popular for several years because of their ability, real or perceived, to help fight against ageing. But which of them offers the greatest potency?

A lovely, happy, older couple
Anti-ageing: senolytics, the best way to stay young

Do you want to delay the negative effects of ageing and stay fit and healthy for as long as possible, to get the most out of life and time spent with loved ones? Discover senolytics, the ultimate weapon for fighting the ageing process.

Small bowl of dried goji berries on a table
The multiple benefits of goji berries

A superfruit used for more than 2000 years in traditional Chinese medicine, the goji berry has become increasingly popular in the West because of its high content of vitamins and antioxidants. Discover its various benefits.

Elderly, senescent cell no longer able to divide
What is a senescent cell?

A senescent cell is one whose life cycle has come to a permanent end. In the normal scheme of things, such cells are eliminated from the body by the immune system. But in some cases, this fails to happen and they accumulate in tissues, with potentially serious consequences for health.

Products which must be of interest

Senolytic ComplexSenolytic Complex

Senolytics: a revolutionary formula for destroying the senescent cells responsible for aging

84.00 €(100.59 US$)
+
Mitochondrial FormulaMitochondrial Formula

Rejuvenates senescent cells by generating new mitochondria

59.00 €(70.65 US$)
+
AMPK BoosterAMPK Booster

The cellular enzyme that promotes longevity and reduces fat storage

42.00 €(50.29 US$)
+
Nicotinamide Mononucleotide 125 mgNicotinamide Mononucleotide 125 mg

Stop, rewind! A world first! This NAD+ booster could truly reverse ageing!

59.00 €(70.65 US$)
+
Dragonhead extractDragonhead extract

Anti-aging dragonhead extract that mimics the effects of calorie restriction

42.00 €(50.29 US$)
+
Astragaloside IV 98%Astragaloside IV 98%

Exceptional advance in anti-aging ! Take advantage of our launch offer on the Astragaloside IV + Resveratrol Synergy "Longevity pack -->

98.00 €(117.35 US$)
+
Astragalus ExtractAstragalus Extract

Astragalus glycerine extract in liquid form. The ancient ‘Fountain of Youth’ of Chinese medicine

19.00 €(22.75 US$)
+
-70%
Nicotinamide Riboside 125 mgNicotinamide Riboside 125 mg

"Miracle molecule", "Incredible hidden vitamin"

20.70 €69.00 €(24.79 US$)
+
© 1997-2021 Supersmart.com® - All rights reserved
© 1997-2021 Supersmart.com®
All rights reserved
Nortonx
secure
Warning
ok