AHCC Supplement - Immunostimulant Shiitake Mushroom Root Extract

This dietary supplement has been formulated to offer the benefits of AHCC ), a rare compound developed by Japanese scientists. It is obtained by fermenting an extract of a mushroom popular in Asia and Europe called shiitake (Lentinus edodes). Interest in the health benefits of this mushroom is far from recent however – it has been used for many years in traditional Asian medicine. The result of considerable research, AHCC offers the benefits of a combination of different active principles with immune-stimulant and anti-tumour properties.

What are the benefits of AHCC?

Since it was developed and its therapeutic virtues revealed, AHCC has been used by many thousands of people, its use supported by studies conducted in over 30 university research institutes and 700 hospitals in Japan and across the world.

• Among the active principles in AHCC is the derivative alpha-glucan, polysaccharide recognised for its immune-stimulant effects. It boosts the immune system by stimulating the activity of various groups of white cells including NK (natural killer) cells, recognised as the body's first line of defence against attack.
• The active principles in AHCC also increase concentrations of T and B lymphocytes, white blood cells which act in a specific way against pathogens. These immune-stimulant effects therefore make this fermented shiitake extract a valuable aid in the prevention of various diseases.
• The immune-stimulant properties of AHCC, demonstrated in in vitro and clinical studies, have rapidly attracted the interest of the scientific community for their potential to fight certain cancers. There is a particular focus on AHCC's stimulant effect on NK cells as they are such a vital line of defence against cancer cells.
• Part of the immediate innate immune response, NK lymphocytes are able to recognise and destroy tumour cells within a few hours. Suffice to say that AHCC's stimulation of these ‘killer cells' paves the way for promising new therapeutic perspectives in the fight against cancer.

In order to offer a high-quality immune-stimulant supplement, shiitake extracts are obtained in a laboratory in accordance with GMP and ISO 9100 & 22000 standards, and delivered in capsules containing an optimal 500mg, with a suggested dose of one to two capsules a day. This dose can be adapted to individual needs and the advice of your therapist. For optimal efficacy, AHCC's beneficial effects can be complemented by other natural active principles available to buy at Supersmart such as lactoferrin, a powerful antioxidant with immune-stimulant properties. The formulation Resveratrol Synergy is also a valuable aid with its exceptional antioxidant content, while the patented product AC-11 can help prevent mutations to DNA.

Buy AHCC to support immune health.

1. Meng X, Liang H, Luo L. Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities. Carbohydr Res 2016;424:30–41.
2. Sato K, Kashimoto M. Profile summary of AHCC: composition. In Clinician’s Guide to AHCC. Kulkarni AD, Calder PC. Ito T. Eds.: 24–33; International Congress on Nutrition and Integrative Medicine; 2017
3. Roman BE, Beli E, Duriancik DM, Gardner EM. Shortterm supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutr Res 2013;33:12–7.
4. Nogusa S, Gerbino J, Ritz BW. Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice. Nutr Res 2009;29:139–43
5. Ritz BW, Nogusa S, Ackerman EA, Gardner EM. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr 2006;136:2868–73.
6. Thaiudom S, Piyaniran W, Chutaputthi A. A study of the efficacy of active hexose correlated compound (AHCC) in the treatment of chronic hepatitis C patients at Phramongkutklao Hospital. Med News Thailand 2010;325:13–6
7. Smith JA, Mathew L, Gaikwad A, Rech B, Burney MN, Faro JP, et al. From Bench to Bedside: Evaluation of AHCC Supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections. Front Oncol 2019;9:173
8. Lee N., Shin M. S., Kang I. T-cell biology in aging, with a focus on lung disease. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2012;67A(3):254–263. doi: 10.1093/gerona/glr237
9. Schultz-Cherry S. Role of NK cells in influenza infection. Current Topics in Microbiology and Immunology. 2015;386:109–120. doi: 10.1007/82_2014_403.
10. Morvan M. G., Lanier L. L. NK cells and cancer: you can teach innate cells new tricks. Nature Reviews. Cancer. 2016;16(1):7–19. doi: 10.1038/nrc.2015.5.
11. Sharma P., Allison J. P. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell. 2015;161(2):205–214. doi: 10.1016/j.cell.2015.03.030.