Clinical evaluation of Daily 3®
under medical supervision in an independent laboratory after 3 months. Among the participants:
See the study
Seems to provide more energy
Un indispensable!
absolument indispensable
effectiveness (french please!) et conformité question stupide affaire de spécialiste J'espère que ça convient
Il est genial
Indispensable !
under medical supervision in an independent laboratory after 3 months. Among the participants:
See the study
Vitamin B12 / Vitamin B6 / Vitamin B1 / Vitamin B2 / Vitamin B3 / Vitamin B5 / Vitamin C / Magnesium / Taurine / Inositol / QuercetinVitamine B12 / Vitamine B6 / Vitamine B1 / Vitamine B2 / Vitamine B3 / Vitamine B5 / Vitamine C / Magnésium / Taurine / Inositol / Quercétine
Vitamin D3 / Vitamin C / Zinc / Selenium / Vitamin A / Green tea extract / Grape seed extract / Quercetin / Olive extract / Pine bark extract
Reduced glutathione / Pterostilbene / Tocotrienols / Green tea extract / Olive extract / Vitamin C / Vitamin E / Lycopene / Grape seed extract / Quercetin / Pine bark extract
Magnesium / Inositol / Taurine / Vitamin B12 / Vitamin B6 / Vitamin B1 / Luteolin / Apigenin / Blueberry / Olive extract / Grape seed extract / Quercetin / BioPQQ® / Nicotinamide riboside
Vitamin K2 / Vitamin K1 / Vitamin E / Chromium (Crominex® 3+) / Zinc / Selenium / Boron / Olive extract / Pine bark extract / Lycopene / Pterostilbene / Blueberry
Lutein / Zeaxanthin / Vitamin A / Lycopene / Vitamin C / Vitamin E / Zinc / Blueberry
Zinc / Selenium / Vitamin B6 / Vitamin B12 / Quatrefolic® / Vitamin E / Chromium (Crominex® 3+) / Grape seed extract / Olive extract
Vitamin D3 / Vitamin K2 / Vitamin K1 / Vitamin C / Zinc / Boron / Magnesium / Grape seed extract / Olive extract
Chromium (Crominex® 3+) / Magnesium / Zinc / Vitamin B3 / Vitamin B6 / Quercetin / Green tea extract / Olive extract
Recommended Daily Allowances (RDAs) are minimums determined to prevent deficiencies, but are not optimal for vitality, immunity or longevity. Daily 3® goes further with high, scientifically justified dosages. Here are a few examples:
Regularly awarded
Advanced forms for optimal assimilation:
4 branded ingredients
No iron or copper
Extraordinary amount of vitamin D3
Constantly revised formula
BioPQQ® (nM)
Increase in mitochondria with BioPQQ® intake
NAD+ concentration with age
NAD+ concentration with age
| Daily dose: 3 capsules Number of doses per pack: 30 |
Amount per dose |
| BioPQQ® (Pyrroloquinoline quinone) | 10 mg |
| Nicotinamide riboside | 10 mg |
| Vitamin A (1000 IU beta-carotene, 500 IU palmitate) | 1500 IU |
| Vitamin D3 (cholecalciferol) | 1000 IU |
| Vitamin K1 (phylloquinone) | 100 mcg |
| Vitamin K2 (Menaquinone) | 75 mcg |
| Vitamin B1 (thiamine hydrochloride) | 15 mg |
| Vitamin B2 (riboflavin) | 20 mg |
| Vitamin B3 (niacinamide) | 60 mg |
| Vitamin B5 (calcium pantothenate) | 30 mg |
| Vitamin B6 (pyridoxal 5-phosphate) | 15 mg |
| Vitamin B12 (methylcobalamin) | 300 mcg |
| Vitamin C (ascorbic acid, ascorbyl palmitate) | 300 mg |
| Vitamin E (d-alpha tocopheryl succinate, with mixed tocopherols) | 40 mg |
| Biotin | 500 mcg |
| Quatrefolic® (6S)-5-methyltetrahydrofolic acid (from 370 mcg of 54-59% glucosamine salts and (6S)-5-methyltetrahydrofolic acid) | 200 mcg |
| Boron (calcium borogluconate) | 1 mg |
| Chromium (Crominex® 3+) | 200 mcg |
| Iodine (Ascophyllum nodosum) | 150 mcg |
| Magnesium (magnesium glycinate) | 80 mg |
| Manganese (gluconate) | 1 mg |
| Molybdene (citrate) | 50 mcg |
| Selenium (sodium selenate, selenomethionine) | 50 mcg |
| Zinc (gluconate) | 15 mg |
| Taurine | 150 mg |
| Reduced glutathione | 50 mg |
| Inositol | 20 mg |
| Lycopene | 5 mg |
| Tocotrienols | 3 mg |
| Lutein | 2 mg |
| Zeaxanthin | 1 mg |
| Green tea extract (30% EGCG + polyphenols) | 100 mg |
| Grape seed extract (95% OPC) | 25 mg |
| Bioperine® | 5 mg |
| Pterostilbene | 50 mg |
| Rutin | 50 mg |
| Quercetin | 50 mg |
| Bilberry 25% antocyanidins | 30 mg |
| Luteolin | 8 mg |
| Apigenin | 25 mg |
| Olive extract (20% oleuropein) | 20 mg |
| Pine bark extract (95% proanthocyanidins) | 20 mg |
|
Other ingredients: acacia gum, white rice flour. Bioperine® : Sabinsa Corporation — Crominex® 3+, Natreon Inc, USA. Quatrefolic®, Gnosis, Italy. BioPQQ®, MGC, Japan. |
|
BioPQQ® contains pyrroloquinoline quinone (PQQ), a human enzymatic cofactor innolved in redox reactions. It plays a role in creating mitochondria, the cells' powerhouses, and is attracting the attention of brain nutrition researchers.
Nicotinamide riboside is a derivative of niacin (vitamin B3) which helps to maintain normal energy metabolism and reduce fatigue. It is involved in synthesising NAD+, a key coenzyme in cellular energy production.
Vitamin A is a fat-soluble vitamin that contributes to the maintenance of normal skin, vision and mucous membranes. It participates in the normal functioning of the immune system, in iron metabolism and plays a role in cellular specialisation.
Vitamin D3 is the form of vitamin D that our skin naturally synthesizes through exposure to the sun. It contributes to the maintenance of normal teeth and bones, the normal functioning of the immune system as well as the normal absorption of calcium and phosphorus.
Vitamin K1 (phylloquinone) is a form of vitamin K found in significant quantities in dark green leafy vegetables and vegetable oils. Vitamin K contributes to normal blood clotting and the maintenance of normal bones.
Vitamin K2 (menaquinone) is a form of vitamin K synthesized by bacteria in the intestinal flora. It is also found in animal products. Vitamin K contributes to normal blood clotting and the maintenance of normal bones.
Vitamin B1, or thiamine, is a water-soluble vitamin found in brewer's yeast, seeds, meat and whole grains. It contributes to the maintenance of normal energy metabolism as well as the normal functioning of the nervous system and the heart.
Vitamin B2, or riboflavin, is a water-soluble vitamin mainly contained in foods of animal origin. It contributes to the protection of cells against oxidative stress, the maintenance of normal skin and vision and the reduction of fatigue.
Vitamin B3, or niacin, is a water-soluble vitamin found in poultry, fish and organ meats. It contributes to normal energy metabolism, the normal functioning of the nervous system, the maintenance of normal skin and the reduction of fatigue.
Vitamin B5 (pantothenic acid) is a water-soluble vitamin found in liver, cereals and dairy products. It contributes to normal mental performance as well as the normal synthesis and metabolism of steroid hormones and vitamin D.
Vitamin B6 is a water-soluble vitamin found in abundance in offal, legumes, and cereals. It contributes to the normal formation of red blood cells, the regulation of hormonal activity as well as the normal functioning of the immune and nervous systems.
Vitamin B12 is a vitamin found exclusively in foods of animal origin. It contributes to the normal functioning of the nervous system and the immune system, the normal formation of red blood cells and the reduction of fatigue.
Present in peppers and citrus fruits, vitamin C is a water-soluble vitamin that contributes to the protection of cells against oxidative stress, the normal functioning of the immune system, the reduction of fatigue, and the normal formation of collagen.
Vitamin E is a fat-soluble vitamin that exists in two forms: tocopherols and tocotrienols. It is mainly found in edible oils and oilseeds. It contributes to the protection of cells against oxidative stress.
Biotin is another name for vitamin B8, a water-soluble vitamin involved in the normal functioning of the nervous system, normal energy metabolism, and normal psychological function. Biotin also contributes to healthy skin and hair.
Quatrefolic® is a patented and bioactive form of so-called fourth generation vitamin B9 (folate). Vitamin B9 contributes to the normal functioning of the immune system, normal blood formation and the growth of maternal tissues during pregnancy.
Boron is a naturally-occurring trace-element found in rock, water and plant foods. Though its function as an essential nutrient in humans has yet to be defined, several studies point to a role in the metabolism of certain minerals and macronutrients.
Chromium is a trace-element present at very low concentrations in the body. It is found in brewer's yeast and calves' liver, amongst others. It supports normal metabolism of macronutrients and helps maintain normal blood sugar levels.
Crominex® 3+ is a form of trivalent chromium, a trace element essential to health which is primarily found in brewer's yeast and in liver. Chromium supports normal metabolism of macronutrients and helps maintain normal blood sugar levels.
Iodine is a trace element fundamental to the body's integrity. Abundant in seafood, it supports normal thyroid, skin and nervous system function as well as normal energy metabolism.
Ascophyllum nodosum is a brown seaweed harvested from the cold waters of the North Atlantic. Rich in essential nutrients (vitamins, minerals, protein, polysaccharides and polyphenols), it supports digestive health. It also has potential benefits for fat absorption and weight control.
Magnesium is a mineral which, amongst others, helps to reduce fatigue and maintain good muscle, psychological and nervous system function. It is found in cocoa, pulses and oilseeds.
Manganese is an essential trace-element. It helps maintain normal energy metabolism, as well as formation of bone and connective tissue and also protects cells against oxidative stress.
Molybdenum is an essential trace-element present in trace amounts in the body. It is mainly stored in the liver and kidneys. It supports normal metabolism of the sulfur-containing amino acids that make up proteins.
Selenium is an essential trace element that contributes to the normal functioning of the thyroid and immune system. It participates in normal spermatogenesis, in the protection of cells against oxidative stress and in the maintenance of normal hair and nails.
Selenomethionine is the most bioavailable form of selenium. Selenium helps to maintain healthy skin, normal immune system and thyroid function and protection of cells against oxidative stress.
Zinc is an essential trace element. It contributes to the protection of cells against oxidative stress, to normal DNA synthesis, to the normal functioning of the immune system as well as to the maintenance of normal skin, hair, vision and bones.
Taurine is a non-essential sulfur-containing amino acid. Equipped with antioxidant properties, it supports vitality, heart health and muscle functioning. It plays an ergogenic role in athletes by improving endurance during periods of intense effort.
Reduced glutathione is the active form of glutathione, a powerful endogenous protector found in every cell in the body, especially in the liver. It is involved in the body's detoxification processes and in maintaining redox balance.
Inositol is a sugar present in every cell in the body. It is particularly abundant in the eye lens, the kidneys, the testicles and the brain.
Lycopene is a naturally-occurring pigment from the carotenoid family which gives tomatoes, watermelon and berries their red colour. Best-absorbed with a little fat, it accumulates mainly in the liver and prostate.
Tocotrienols form a class of vitamin E that is very active at plasma membranes and enzyme active sites. They come in 4 variants (alpha, beta, gamma, delta). Vitamin E contributes to the protection of cells against oxidative stress.
Lutein is yellow-orange pigment from the carotenoid family found in eggs yolk, dark green vegetables and squash. It accumulates preferentially in the macula of the retina, the part responsible for central vision.
Zeaxanthin is a yellow plant pigment from the xanthophyll family. It is found, among other things, in corn kernels and egg yolk. It accumulates in the center of the macula of the retina, the area of maximum acuity of the eye in daytime lighting.
Non-oxidised, green tea has a high content of catechins including epigallocatechin gallate (EGCG), which is thought to affect various mechanisms involved in cell proliferation. It also contains an amino acid called L-theanine which has a calming effect.
Epigallocatechin gallate (EGCG) is a catechin belonging to the flavonoid family. This natural pigment is one of the best-known protective compounds in green tea, and is at the centre of many studies investigating the processes of angiogenesis and cell proliferation.
OPC stands for 'oligomeric proanthocyanidins'. These flavonoids are primarily extracted from grapeseed or maritime pine bark, both of which support vascular health. They bind to collagen in blood vessel walls.
Grape seeds have strong antioxidant activity due to their content of oligoproanthocyanidins (OPCs) which have a beneficial effect on the circulation. They are also showing promise in terms of cell protection in general.
Bioperine® is an extract of black pepper (Piper nigrum) standardised to 95% piperine, the highest percentage on the market. Black pepper helps support digestion and immunity. Piperine optimises the bioavailability of various compounds including curcumin.
Pterostilbene is a bioavailable form of resveratrol, a protective compound found primarily in grapes and berries where it protects them from environmental stressors. It is 2-4 times more absorbable than resveratrol.
Rutin, or sophorin, is a natural flavonoid chemically close to quercetin that is found in the skins of citrus fruits and apples, grapes and buckwheat. Studies suggest that it exerts protective effects at the cellular and venous level.
Quercetin is a flavonoid naturally present in plants (berries, onions, citrus fruits, tea, etc.). In vitro and in vivo studies have looked at its link with immune functioning and its potential effects in the regulation of allergies.
Bilberry is an antioxidant berry from the Vaccinium genus native to North America. A source of anthocyanins, it supports vascular, venous and ocular health and helps protect gastric and intestinal mucosa.
Luteolin is a flavonoid first isolated from reseda luteola, or dyer's weed. It is also found in celery, peppers, rosemary and thyme. Scientists are working to understand how it interacts with chemical factors in inflammation.
Apigenin is a chemical compound belonging to the flavonoid family, found in parsley, plantain, rosemary, camomile and passiflora. It is thought to interact with certain cell signalling pathways involved in regulating inflammation and apoptosis.
This extract is obtained from olives, the oil of which is rich in polyphenols and omega-9 fatty acids and forms the basis of the Mediterranean diet. It has been shown that replacing saturated fats in the diet by unsaturated fats lowers blood cholesterol.
Pine bark extract is obtained from maritime pine (Pinus pinaster) and Scots pine (Pinus sylvestris). Both support respiratory health. Maritime pine, rich in oligoproanthocyanidins (OPCs), supports vascular health.
Proanthocyanidins are polyphenol compounds from the tannin family which provide colour to many plant-source foods such as red berries, wine and cocoa. Their effects on free radicals are currently under investigation.
Sharma C, Donu D, Cen Y. Emerging Role of Nicotinamide Riboside in Health and Diseases. Nutrients. 2022 Sep 20;14(19):3889. doi: 10.3390/nu14193889. PMID: 36235542; PMCID: PMC9571518.
Ying, 2008 W. Ying NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences Antioxid. Redox Signal., 10 (2008), pp. 179-206
Abhirup Das, George X. Huang et al. Impairment of an Endothelial NAD -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging. Cell, 2018; 173 (1): 74 DOI: 10.1016/j.cell.2018.02.008
Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 1;285(1):142-52. doi: 10.1074/jbc.M109.030130. Epub 2009 Oct 27.
Min Z, Wang L, Jin J, Wang X, Zhu B, Chen H, Cheng Y. Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis Via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression. J Cancer. 2014 Jul 29;5(7):609-24. doi: 10.7150/jca.9002. eCollection 2014.
Masahiko Nakano , Tetsuro Yamamoto , Hisayoshi Okamura , Akira Tsuda , and Yasuyuki Kowatari. Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep. Functional Foods in Health and Disease 2012, 2(8):307-324
Anne Marie Uwitonze, Mohammed S. Razzaque. Role of Magnesium in Vitamin D Activation and Function. The Journal of the American Osteopathic Association, 2018; 118 (3): 181 DOI: 10.7556/jaoa.2018.037
Seelig MS. Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review) J Am Coll Nutr. 1994;13:429–46. doi: 10.1080/07315724.1994.10718432.
Gommers LM, Hoenderop JG, Bindels RJ, de Baaij JH. Hypomagnesemia in Type 2 Diabetes: A Vicious Circle? Diabetes. 2016;65:3–13. doi: 10.2337/db15-1028
Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. Schürks M, Glynn RJ, et al. BMJ. 2010 Nov 4;341:c5702.
Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Aggarwal BB, Sundaram C, et al. Biochem Pharmacol. 2010 Dec 1;80(11):1613-31.
G. Tavoularis, P. Hébel, Fruits et égumes : les Français suivent de moins en moins la recommandation, Consommation & Modes de vie N°CMV292, juillet 2017
I have known and recommended SuperSmart supplements for years. The supplements are well researched, well dosed and safe, and you can find ‘what you can't find anywhere else’. I prefer Daily 3, which remains ‘my’ favourite multivitamin/mineral supplement. The delivery service is reliable and I have never been disappointed by the brand.
I recommend SuperSmart when I work in micro-nutrition because the formulations are in the most readily available form for the body, well tolerated, and the dosages allow you to take fewer tablets for better assimilation, such as Daily 3, which is ultra-complete, for example.
I particularly appreciate the SuperSmart laboratory for the quality of the nutrients it offers and the synergies specific to different issues. These blends are always judiciously composed with forms that are very well assimilated by the body. I really appreciate Daily 3 when looking for a more complete multivitamin supplement. I can only recommend this laboratory to people who want to take care of their health!
The dosages are correct, with no side effects. The prices are very reasonable (e.g. Daily 3). Fast delivery and well packaged. Thank you.
Our team of nutrition experts and scientists has the answers.
Daily 3® composition is regularly updated in order to push back the boundaries of excellence even further and incorporate the latest scientific advances.
For the first time, we have added nicotinamide riboside.
The addition of nicotinamide riboside to Daily 3® (10mg per daily dose) is a major development given this compound’s reputation within the scientific community. It’s a highly promising anti-ageing substance which is only just starting to be available to the public. Once ingested, it crosses the intestinal barrier with ease, where it is converted into an essential coenzyme called NAD (nicotinamide adenine dinucleotide), production of which declines with age. It’s clear that NAD helps fight against ageing by increasing the level of sirtuins, the ‘longevity proteins’ involved in many physiological mechanisms.
The amount of BioPQQ® has been doubled and that of lycopene increased (from 2 to 5 mg).
Studies show that PQQ stimulates the growth of new mitochondria, the organelles responsible for cellular energy production, as well as that of nerve growth factor (NGF) (5-6). One clinical study demonstrated that 8 weeks’ supplementation with PQQ led to improvements in mood, fatigue, and sleep quality (7). In this new version of Daily 3®, Supersmart has increased PQQ levels to 10mg in line with the dose used in most of these studies.
The amount of magnesium has been doubled.
A recent study showed that one in two of us has inadequate magnesium levels (8). This is a growing trend due to rapid changes in dietary habits, greater stress levels (9), increasingly common disruption of the acid-base balance, and the rising incidence of diseases like diabetes (10) and metabolic syndrome. And the consequences of such inadequacy are far from trivial: nerve and muscle hyperexcitability, cramps, tingling, hypersensitivity to stress, insomnia, increased heart rate, more frequent migraines, emotional over-sensitivity, fatigue, muscle pain...
In light of this, Supersmart has doubled the amount of magnesium, taking the total daily dose to 80 mg.
Resveratrol has been replaced by pterostilbene.
Daily 3® now features pterostilbene, a nutrient from the same family as resveratrol but with much better bioavailability (80% for pterostilbene as against 20% for resveratrol).
It now contains a better form of vitamin B6.
Scientists have recently demonstrated that the active form of vitamin B6 in the body is pyridoxal-5-phosphate. Pyridoxine has therefore been replaced by this more bioavailable form.
The amount of vitamin K1 has been reduced (from 140 µg to 100 µg) but vitamin K2 has been added (75 µg).
There are two main forms of vitamin K: phytomenadione (K1) and menaquinone (K2).The most recent studies suggest that vitamin K1 acts more directly on coagulation, while K2 works on the calcification of soft tissue. It therefore makes sense to offer both forms in our formulation.
The amount of vitamin A is now lower.
As recent studies have shown that the risk of vitamin A deficiency in developed countries is now low, Supersmart has reduced the amount of this vitamin in order to make room for other beneficial nutrients. It’s important to stress that the previous version never presented any risk of ‘over-dosing’, as beta-carotene is only converted into vitamin A when the body needs it.
Total tocopherols and gamma tocopherols have been removed.
Some meta-analyses have questioned the wisdom of regular supplementation with vitamin E at doses above 400IU a day (11). For those with very low starting levels of oxidative stress, it could actually present a slight health risk. While such conclusions remain the subject of debate, Supersmart has chosen to remove the synthetic tocopherols from Daily 3® and to retain only the natural vitamin E and tocotrienols, which according to the scientific literature, are more active (12).
Molybdene, selenium and zinc have all been reduced.
We’ve chosen to reduce the amount of these three trace elements and bring them in line with recommended daily amounts since the latest studies have shown no benefit in exceeding these levels. We have, of course, retained the same exceptional forms which offer optimal bioavailability: molybdene citrate, selenomethionine (obtained naturally) and zinc gluconate.
Take three capsules a day, one with each of your three main meals: it’s never been easier to maintain good health.
This product’s capsules are composed of HPMC (hydroxypropyl methylcellulose), a plant substance derived from cellulose. HPMC is widely used for medicines and dietary supplements. It contains no animal ingredients, is recognised as safe by health authorities and is considered more sustainable than synthetic alternatives.
july 6 2025
Seems to provide more energy
february 5 2025
Un indispensable!
december 24 2024
absolument indispensable
november 25 2024
effectiveness (french please!) et conformité question stupide affaire de spécialiste J'espère que ça convient
november 19 2024
Il est genial
Hello Elisabeth,
Thank you very much for your positive feedback. We are delighted to know that you are fully satisfied with your experience.
Please donât hesitate to reach out if you have any questions or need assistance.
Best regards,
The Supersmart Team