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Polypodium leucotomos Extract Supplement
Polypodium leucotomos Extract Supplement
0549Polypodium leucotomos Extract SupplementSize
Sans nano-particulesSans glutenVegan
Polypodium leucotomos Extract
Care of skin, hair and nails
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25.00 €(25.62 US$) in stock
Polypodium Leucotomos Extract is an extract of tropical fern with skin anti-ageing properties.
  • Has antioxidant, soothing and immunomodulatory effects.
  • Neutralises the free radicals, offering relief and protection of the skin.
  • Encourages the preservation of skin tissue structure.
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25.00 €
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Leaf of the medicinal plant Polypodium Leucotomos

Polypodium leucotomos repairs, soothes and protects the skin

Polypodium leucotomos Extract is a top quality dietary supplement recognised for its ability to repair, soothe and protect the skin. It is primarily composed of Polypodium leucotomos, a fern that grows in tropical forests. Native to Honduras, this unique plant has a long history of use in traditional South American medicine, practitioners of which were quick to recognise its efficacy at regenerating skin tissue.

What benefits does Polypodium leucotomos Extract offer?

Anti-inflammatory, photoprotective, antioxidant ...

The supplement Polypodium leucotomos Extract is designed for anyone who wants to improve the condition of their skin whether they suffer from a skin problem or not.

This tropical fern extract has anti-inflammatory, photoprotective, antioxidant and immunomodulatory properties.

Preserving skin tissue and protecting skin cell DNA

This regenerative and soothing formulation has been carefully developed, drawing on the latest scientific studies which show that this plant extract:

  • helps preserve the structure of skin tissues;
  • protects skin cell DNA;
  • has soothing and immunomodulatory effects on the skin;
  • and combats oxidative stress by neutralising free radicals and reactive oxygen species, especially superoxide anion.

How does this tropical plant help to fight inflammation and redness?

Relief of eczema and psoriasis

Atopic eczema, or atopic dermatitis, is a very common inflammatory disease characterised by redness and intense itching. One study of 105 child and adolescent sufferers showed that a course of Polypodium leucotomos extract supplements was able to significantly reduce skin inflammation and relieve itching. (1)

Certain molecules in the plant may act by inhibiting the expression of pro-inflammatory cytokines in the skin in the case of eczema, psoriasis and other inflammatory diseases.

Reduction in reactions which cause skin redness

As with atopic eczema, many skin diseases (infectious, irritative, allergic …) present with ‘erythematous’ plaques, red patches which turn white when pressed. Polypodium leucotomos is specifically able to prevent this erythema from developing.

Oral supplementation with this fern extract has been observed to reduce phototoxic erythematous reactions and significantly improve skin recovery. (2) (3)

How does this fern extract slow down photo-ageing?

Polypodium leucotomos restricts UV’s harmful effects

Polypodium leucotomos’ effects in preventing skin damage are also due to its photoprotective properties – the power to protect the skin from the negative effects of the sun’s rays. This ability may have been acquired in the course of the plant’s evolutionary aquatic-to-terrestrial transition (4)

The fern’s components may act by inhibiting the photoisomerisation and photodecomposition of trans-urocanic acid ordinarily caused by UV exposure. Polypodium leucotomos extract may ultimately result in the strong>inhibition of apoptosis (programmed cell death) caused by the sun’s rays. (5) (6)

An American study from 2015 showed that taking an extract of this plant (in the form of a 240mg supplement, twice a day for 60 days) was an effective way of reducing UV-induced damage. It also confirmed the absence of any contraindications. (7)

Taking a Polypodium leucotomos extract is also beneficial in the treatment of idiopathic photodermatitis: it alleviates polymorphic light eruptions, actinic prurigo and solar urticaria. (8)

It fights skin ageing and protects DNA

Polypodium leucotomos also plays an important role in preventing photoageing. It works, in particular, by strengthening the fibroblasts in skin tissues and supporting keratinocyte proliferation, which delays the appearance of wrinkles and prolongs the skin’s suppleness. (9)

As we know, the sun can cause serious damage by adversely affecting the DNA strands in our cells. Over time, these changes can go on to cause cancer. A course of Polypodium leucotomos can help reduce this risk by protecting the genetic composition of skin cells.

Reduce your oxidative stress

A plant rich in p-coumaric, caffeic and ferulic acids ...

Naturally rich in antioxidants, this plant extract provides an excellent way of fighting the oxidative stress that attacks the body. The compounds it contains include:

  • p-coumaric acid
  • l'caffeic acid
  • l'vanillic acid
  • and ferulic acid. (10)

The perfect composition for eliminating reactive oxygen species (ROS)

These various acids help eliminate free radicals naturally (as well as other reactive oxygen by-products such as superoxide anion), all of them unstable molecules which ‘clutter up’ the body, damage cells and proteins, and are a cause of cancer and degenerative diseases. (11) (12)

An immunomodulatory role: re-pigmenting and protecting the skin

<3>Blocking auto-immune responses harmful to the skin

Scientists have also demonstrated the immunomodulatory properties of this medicinal plant, particularly its effect on vitiligo. The de-pigmentation in vitiligo is the result of an over-reaction by the immune system which eventually destroys melanocytes – the cells responsible for skin colour.

A common approach to treating vitiligo is to expose the body to UVB rays in order to stimulate re-pigmentation of the areas affected. A Dutch study observed greater re-pigmentation of patients’ skin when this kind of UVB phototherapy was combined with an oral dose of Polypodium leucotomos. It seems the plant has an immunomodulatory effect which may block excessive auto-immune responses in patients. (13)

Boosting Langerhans cells

Conversely, the components of this tropical fern are also able to stimulate the immune defences. Let’s take the example of Langerhans cells, responsible for repairing sun-induced damage to the skin barrier.

As these cells gradually become degraded by UV rays, they themselves become less effective. Polypodium leucotomos has been shown to protect Langerhans cells and thus boost the skin’s immunological defences. (14)

What exactly does Polypodium leucotomos Extract contain?

Polypodium leucotomos Extract is formulated exclusively with natural ingredients, specifically chosen for their positive effects on the skin.

Polypodium leucotomos

The supplement’s principal ingredient, Polypodium leucotomos flourishes in the forests of South and Central America, one of many treasures that grow deep within such environments. The value of this fern has long been recognised by these regions’ indigenous healers.

It was introduced to Europe at the end of the 18th century by a botanist commissioned by the Spanish court, and it continues to surprise with its wide range of curative properties:relief of inflammation, regeneration, re-pigmentation, UV protection, etc.

More specifically, Polypodium leucotomos Extract contains an extract of the leaf of this medicinal plant, and thus purely its active ingredient providing guaranteed maximum efficacy.

Acacia gum and rice flour

Acacia gum is a resin obtained from the Acacia senegal tree, which grows in the dry regions of tropical Africa. This sap exudate is high in fibre, carbohydrates and proteins. The supplement’s composition is completed with rice flour which helps give it shape and stability.

How should Polypodium leucotomos be taken?

Two capsules a day

We recommend taking 2 capsules a day.

This balanced dose will provide everything you need to improve, relieve and strengthen your skin tissues, though be aware it will take a few weeks before all the benefits of a course of Polypodium leucotomos are fully appreciated.

Some additional supplements to consider

If you suffer from psoriasis , you might want to take a look at Fumaric Acid. This carefully-developed supplement primarily contains fumaric acid, an unsaturated dicarboxylic acid with highly-effective immunoregulatory properties. Fumaric acid is excellent for controlling flaking of the skin. It is widely used for treating moderate to severe psoriasis, especially in Germany. (15)

And for protecting and strengthening your skin over the long term, discover too the moisturising and anti-wrinkle powers of Skin Ceramides, a classic in its field, patented and supported by six clinical studies.

Daily serving: 2 capsules
Number of servings per bottle: 45
Quantity per serving
Polypodium leucotomos 4:1 leef extract 1,000 mg
Other ingredients: Acacia gum, rice flour.

Each vegetarian capsule contains 500 mg of Polypodium leucotomos 4:1 leef extract.
Directions for use
Take one to two capsules a day in the morning, 30 minutes before exposure to the sun, or as recommended by your therapist. You should still use topical sun products when exposed to the sun.
4.8 /5 4 reviews
5.0 / 5
5.0 / 5
Value for money
4.7 / 5

Reviews 4
75 %

Muy contento por todo. Gracias.
Je conseille le Polypodium leucotomos en association avec le bêta carotène (et la crème de protection solaire, bien sûr) pour protéger votre peau de la lucite estivale
Fantástico, si no fuera por este producto me encontraría fatal.Louso desde hacer años.
No es demasiado caro.
Muy bueno

W. Koert
Sinds we dit gebruiken, smeren we ons niet meer in en zijn we toch niet verbrand door de zon, al proberen we wel een beetje op te passen. Voor het herstellen van de huid, bijvoorbeeld de ouderdomsvlekken zullen we het nog langer moeten gebruiken.
  1. Ramírez-Bosca A, Zapater P, Betlloch I, et al. Polypodium leucotomos extract in dermatitis: a randomized, double-blind, placebo-controlled, multicenter trial. Actas Dermosifiliogr. 2012;103(7):599–607.
  2. Korman AM, Reynolds KA, Nabhan F, Konda B, Shah MH, Kaffenberger BH.-induced Phototoxic Drug Eruption Treated with Polypodium Leucotomos Extract: A Case Report and Review of the Literature. J Clin Aesthet Dermatol. 2019;12(10):35–38.
  3. Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol. 2004;51(6):910–918. doi:10.1016/j.jaad.2004.06.027.
  4. Bhatia N. Polypodium leucotomos: a potential new photoprotective agent. Am J Clin Dermatol. 2015;16(2):73–79.
  5. Capote R, Alonso-Lebrero JL, García F, Brieva A, Pivel JP, González S. Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition. J Photochem Photobiol B. 2006;82(3):173–179.
  6. Palomino, Olga. (2014). Current knowledge in Polypodium leucotomos effect on skin protection. Archives of dermatological research. 307.
  7. Nestor MS, Berman B, Swenson N. Safety and Efficacy of Oral Polypodium leucotomos Extract in Healthy Adult Subjects. J Clin Aesthet Dermatol. 2015;8(2):19–23.
  8. Caccialanza M, Percivalle S, Piccinno R, Brambilla R. Photoprotective activity of oral polypodium leucotomos extract in 25 patients with idiopathic photodermatoses. Photodermatol Photoimmunol Photomed. 2007;23(1):46–47.
  9. Alonso-Lebrero JL, Domínguez-Jiménez C, Tejedor R, Brieva A, Pivel JP. Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells. J Photochem Photobiol B. 2003;70(1):31–37.
  10. Gombau L, García F, Lahoz A, et al. Polypodium leucotomos extract: antioxidant activity and disposition. Toxicol In Vitro. 2006;20(4):464–471.
  11. González S, Pathak MA. Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomos. Photodermatol Photoimmunol Photomed. 1996;12(2):45–56.
  12. Philips N, Conte J, Chen YJ, et al. Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-beta by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells. Arch Dermatol Res. 2009;301(7):487–495.
  13. M.-A. Middelkamp‐Hup, J.-D. Bos, F. Rius‐Diaz, S. Gonzalez, W. Westerhof, Treatment of vitiligo vulgaris with narrow‐band UVB and oral Polypodium leucotomos extract: a randomized double‐blind placebo‐controlled study, J Eur Acad Dermatol Venereol. 2007 Aug;21(7):942-50.
  14. Gonzalez S. et al., Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin, Photodermatology Photoimmunology & Photomedicine, 1997, 13:50-60.
  15. Termeer C, Reinhold U, Dirschka T, von Kiedrowski R, Kurzen H. Long-term use of fumaric acid esters for the treatment of psoriasis in daily practice [published online ahead of print, 2019 Nov 12]. J Dermatolog Treat. 2019;1–7. doi:10.1080/09546634.2019.1688234.

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Polypodium leucotomos Extract
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