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After nearly 15 years' absence in Europe, L-tryptophan, one of the essential amino acids in the diet, is back - available to buy once more in an authorised nutritional supplement. A precursor of serotonin, melatonin and niacin, tryptophan is a vitally important substance. Discovered in 1901, it has been used for decades to relieve depression, promote sleep or aid with weight loss.
What benefits do studies show about L-Tryptophan?
Serotonin plays a key role in many of the body's functions, and particularly in depression, anxiety, mood and appetite control. Many people eat excessive amounts of carbohydrates when they feel stressed, depressed or anxious. This results in a rise in cerebral serotonin and a temporary feeling of well being and security, but at the same time, an increase in fat stores. Tryptophan supplementation improves psychological state without inducing increases in the amount of stored fat. Several studies have demonstrated the benefits and efficacy of tryptophan.
- Serotonin cannot cross the blood-brain barrier, so when levels are inadequate, only supplementation with either of its two precursors - tryptophan or 5-HTP - can raise them effectively.
- The first studies using tryptophan to influence mood were conducted in the Fifties. Tryptophan supplementation was shown to be effective and free of side-effects in subjects suffering from mild to moderate depression.
- Both on its own and combined with phototherapy, tryptophan is also an effective treatment for SAD (Seasonal Affective Disorder).
- In cases of mild insomnia, tryptophan promotes drowsiness and good quality sleep.
In 1990, its use in supplements was banned, after a single contaminated batch of tryptophan supplied by one Japanese manufacturer apparently led to the development of a deadly condition. Its use in drugs, infant formulas and parenteral food products, however, continued unhindered.
What are the differences between L-tryptophan and 5-HTP?
L-Tryptophan and 5-HTP are converted into serotonin following the same metabolic pathway. However, certain people react better to supplementation with L-tryptophan than with 5-HTP. This may be for a number of reasons.
- With L-tryptophan supplementation, the body maintains control over the amount of serotonin produced using the enzyme L-tryptophan hydroxylase.
- When 5-HTP is taken, some of it may find its way to the intestine where it can cause nausea. Besides, since serotonin cannot cross the blood-brain barrier, any serotonin produced outside of the brain is unable to penetrate it.
- In some individuals, certain conditions, including severe depression, can prevent the passage of 5-HTP across the blood-brain barrier - this does not happen with L-tryptophan.
L-tryptophan is available to buy in Supersmart's catalogue, providing benefits as an essential amino acid that is crucial for healthy body function and particularly, for the production of niacin.
What is in L-Tryptophan
november 29 2023
on se sent plus serein ,bon produit
january 28 2022
Quite often needed for the dysthymia persons
june 13 2025
Très bon produit utile pour mon équilibre car tendance à l’anxiété. Je prends 1/2 le matin et l’autre moitié le soir.
Very good product useful for my balance as I tend to be anxious. I take half in the morning and the other half in the evening.
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may 1 2025
En phase de ménopause, cela m'aide beaucoup pour un sommeil agréable et reposant.
In menopause, it helps me a lot for a pleasant and restful sleep.
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march 27 2025
Je prends un comprimé au dîner et un au coucher, ça marche!
I take one tablet at dinner and one at bedtime, it works!
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Bonjour,
Merci beaucoup d'avoir pris du temps pour partager votre expérience.
Bonne journée,
Valérie - Supersmart