Supplementing with spermidine – Benefits and Dosage
Spermidine is an excellent spermidine supplement developed by SuperSmart, pioneers in supplementation in Europe.
With each passing year, the body’s cellular spermidine levels fall inexorably (1). It’s one of the markers of ageing. By taking this supplement, you can significantly increase your intake of spermidine in a totally natural and healthy way.
Spermidine is known to help activate autophagy, a powerful cell detoxification mechanism. In particular, it has positive effects on cardiovascular health and helps combat deviant cell behaviour. This anti-ageing compound thus plays an active part in fighting ageing and extending lifespan (2-3).
What exactly is spermidine?
Spermidine is a polyamine, an organic compound with several amine functions. It is present in all living beings. Formed by putrescine, spermidine is a precursor of spermine.
Spermidine actually gets its name from the fact that it was first discovered in human sperm in 1678. However, it is found in all human cells and in all those of mammals in general, as well as in various foods.
Dietary sources of spermidine
Small amounts of spermidine are found in foods such as soya beans, wheat germ, mushrooms and mature cheeses.
The benefits of the supplement Spermidine
With age, there is an irreversible decline in intracellular levels of spermidine. This supplement enables you to significantly and naturally increase your intake of spermidine. Quite simply, it offers the the best quality and highest content of spermidine on the market.
Let’s now focus on the benefits of this compound. Various studies have shown that spermidine helps to regulate autophagy(4-5).
This cleaning out and recycling process removes damaged or toxic proteins and organelles from cells (6-7). Autophagy, which is essential for protecting the body against all kinds of problems, becomes less effective as we get older. Increasing your intake of spermidine, levels of which also decline with age, helps to reactivate this autophagy mechanism (8).
Spermidine has been shown to help extend life lifespan in various invertebrate models (yeasts, worms, flies) and in human immune cells, by directly inhibiting acetyltransferases, and by maintaining histone H3 in a hypoacetylated state (9).
In particular, it helps to improve blood pressure and cardiac function. A number of observational studies have shown that intake of dietary spermidine is inversely associated with cardiovascular problems (9-11). It also helps to prevent cells from becoming corrupted, has anti-inflammatory properties, neuroprotective effects and plays a role in preventing the decline in stem cells (12-13).
Spermidine has also shown positive effects against glycation. This process, whereby sugars attach to proteins, is a factor in accelerated ageing of tissues (14).
Finally, recent research has shown that diets rich in spermidine are associated with increased longevity in humans (15-16). In short, taking spermidine helps to support good general health, slow down ageing and extend life expectancy.
How should this spermidine supplement be taken?
To obtain maximum benefit from this highly effective ageing regulator, you need to take just 1 or 2 capsules of Spermidine a day. Each capsule contains 150 mg of rice extract standardised to 1% spermidine, providing a daily dose of 3 mg of spermidine.
Advice on how to hold back the ageing process
If you’re looking for ways to slow down the rate at which your body is ageing, here are some key tips to help you stay younger for longer:
- take moderate exercise. To maintain healthy arteries and combat ageing of the heart, you should aim to engage in physical activity (walking, cycling, yoga, housework, gardening …) four or five times a week;
- keep yourself well-hydrated ! As we age, our skin tends to dehydrate. So to reduce the appearance of wrinkles as much as possible, drink a litre and a half of fluid a day (water, tea, herbal tea ...) and use a suitable moisturiser on your skin;
- preserve your memory. To maintain mental ability, you need to keep your brain active by engaging in activities such as crosswords, boardgames, reading, watching films, recalling celebrities’ names, using memory-boosting apps, etc. ;
- reduce pro-oxidant factors by limiting your consumption of barbecued food, charcuterie, fried food, fizzy drinks and alcohol, as well as avoiding smoking and exposure to UV rays … Excessive free radical release causes oxidative stress which accelerates cellular ageing;
- get enough sleep. A lack of sleep can lead to enlarged blood vessels in the brain, which causes a drop in cerebral blood pressure and thus an acceleration in cognitive decline. While we vary in the amount of sleep we need, aim for at least 7 hours a night to help slow down the ageing process.
Other supplements that act synergistically with Spermidine
Alongside a course of spermidine, we recommend taking our famous supplement Senolytic Complex, formulated to eliminate senescent cells, one of the key cause of ageing. This unique formulation contains fisetin, nicotinamide mononucleotide, bromelain, quercetin, black tea ... it is, in short, an amazing supplement combining the best nutrients in this field.
You could also increase your intake of pyrroloquinoline quinone (PQQ), a very specific molecule that helps to regenerate mitochondria, the powerhouses of the body’s cells. We recommend taking Mitochondrial Formula, an anti-ageing supplement that contains two other highly effective compounds: lipoic acid and carnitine.