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Rehab Supplement
Rehab Supplement
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Rehab
Liver and detoxification
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Description
Natural aid to detoxification
  • Provides natural nutrients for stimulating the body’s detoxification mechanisms.
  • Used for alleviating chemical dependency.
39.56 €  
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Rehab Supplement - Natural Nutrients to Support Alcohol Detox Mechanisms

Rehab is a natural detox supplement combining powerful liver-protectivephytonutrients (turmeric, milk thistle …) with cutting-edge catalysts (lipoic acid, vitamin C, glutathione…) involved in the mechanisms of waste elimination. Its synergistic formulation is specifically designed to ‘deep-clean’ the body and provide support for chemical dependency.

The 3 phases of liver detoxification

The liver plays a fundamental role in processing and eliminating toxins (waste products of endogenous metabolism) and toxic substances also known as xenobiotics (tobacco, alcohol, drugs, pesticides …).

Hepatic detoxification thus describes the series of biochemical reactions that take place in the liver to purge the body of these undesirable metabolites. It has three key stages (1):

  • phase I activation: fat-soluble toxins are broken down into oxidised derivatives, primarily by a group of enzymes called Cytochrome P450. These antioxidant mechanisms intervene to counteract the adverse effects of the free radicals formed in the process;
  • phase II conjugation: hydrophilic groups combine with the oxidised derivatives to make them water-soluble and facilitate their elimination;
  • phase III transport: the metabolites are carried away from the liver and excreted via urine, faeces, exhalation or sweat.

What is in the detox supplement Rehab?

Rehab is based on a combination of proven active principles aimed at promoting this important detoxification cycle and making it run smoothly :

  • extract of chrysanthellum (Chrysanthellum americanum). Known as ‘golden camomile’, this plant originates from South America and is traditionally used in Africa, and more specifically in Nigeria, as support for digestive problems (2) ;
  • vitamin C: it helps protect cells against oxidative stress, by boosting neutralisation of the free radicals produced during phase 1 detoxification (3) ;
  • reduced glutathione, an essential tripeptide of phase II detoxification (4) ;
  • asparagine. First isolated in asparagus, this non-essential amino acid plays a role in the metabolic conversion of alcohol. One study showed markedly decreased levels of asparagine in the pancreas of ‘alcoholic’ rats (5) ;
  • extract of kudzu. Containing a number of flavonoids (puerarin, diazine and daidzein), this climbing vine with adaptogen properties has been extensively studied in relation to alcohol addiction(6) ;
  • calcium D-glucarate. The natural calcium in fruit and vegetables, this is the keystone of the glucuronidation process, a particular form of conjugation in which chemicals, steroid hormones and other fat-soluble toxins bind to glucuronic acid in the liver (7) ;
  • dimethylglycine. A derivative of glycine, this intermediate compound of liver metabolism is converted by demethylation into glycine, an amino acid involved in glutathione synthesis (8) ;
  • curcumin. This curcuminoid is the most powerful active substance in turmeric (Curcuma longa), a root with antioxidant properties, which helps maintain liver health. A number of studies have shown its ability to modulate the liver’s enzymatic activity and lipid metabolism (9). It is combined with Bioperine® to maximise its bioavailability and efficacy;
  • ellagic acid from pomegranate extract. This polyphenol, abundant in red berries and much-prized by the pharmacological industry, has been widely studied in relation to alcohol-induced liver disorders (10) ;
  • extract of ginger root. Another antioxidant root from the Ayurvedic pharmacopoeia, ginger supports good digestive health and normal sugar metabolism(11) ;
  • silymarin. The active molecule in milk thistle (Silybum marianum), this helps to protect liver cells and promote the production of bile (12). Used for centuries, it has excellent tolerance ;
  • sodium R-lipoate. This sodium salt is a stable and highly-bioavailable form of alpha-lipoic acid, a protective compound produced by the mitochondria and a cofactor of several phase II enzymes. Alpha-lipoic acid also acts as a chelator of lead, a heavy metal that’s toxic at even very low doses (13).

What are the signs of a ‘clogged’ liver?

Excessive partying, drug treatment, unhealthy lifestyle: in circumstances such as these, it’s not always possible for the liver to carry out its purifying role properly (14-15).

Signs of liver function overload vary greatly from one person to another, but one or more of the following symptoms are common:

  • a yellow-ish complexion ;
  • nausea, problematic digestion ;
  • yellow, greasy or sticky stools;
  • a lower threshold for alcohol ;
  • being bothered by smells ;
  • muscle and/or joint pain ;
  • skin disorders (acne, eczema…) ;
  • significant fatigue.

As these various symptoms can also be a sign of more serious liver disease, it’s important to consult your doctor if you are worried.

3 tips for cleansing your liver naturally

If you’re thinking of starting a detox to help regenerate your liver, here are three tips to take on board:

  • lighten your diet. Avoid processed products, as the additives they contain add to the toxic load on your liver (16). Drastically reduce your consumption of gluten, dairy products, fatty meats, and more generally, high-fat, high-sugar and refined products. Instead, increase your intake of fruits and vegetables (raw, steamed or juiced), focusing on cruciferous vegetables, those from the Alliaceae family (onions, leeks, garlic, ...), artichokes and aromatic herbs(17). Aim for lightness and frugality;
  • stay well-hydrated. To help your emunctory organs process and eliminate toxins from your body, make sure you drink enough water – at least 2 litres a day (18). But go easy on the stimulant drinks (coffee, tea…) ;
  • get sufficient rest. Your body has to devote energy to eliminating metabolic waste. But keep up the light exercise (like walking) to gently stimulate your metabolism.

Supplements to combine with Rehab

For those who want to take it a step further, two other detoxifying supplements might also be of interest.

Combining 7 natural extracts including aloe vera, the supplement Colon Cleanse Formula is specifically targeted at the colon, one of the body’s 5 emunctory organs (19).

And the formulation Lectin Flush is a collection of natural substances that bind to lectins, proteins ubiquitous in our diet and implicated in certain cases of digestive hypersensitivity (20).

Composition
Daily serving: 4 capsules
Number of servings per bottle : 30

Quantity
per serving

Chrysantellum americanum (extract 4:1) 200 mg
Vitamin C 100 mg
Reduced glutathione 15 mg
Benfotiamine 50 mg
Asparagine 100 mg
Kudzu (extract 4:1) 400 mg
Calcium D glucarate 75 mg
Dimethylglycine 75 mg
Bioperine® 5 mg
Curcumin (Curcuma longa extract 95% curcumin) 50 mg
Pomegranate extract (40% ellagic acid) 50 mg
Ginger root (extract 4:1) 50 mg
Silymarin (Milk thistle extract 80% silymarin) 100 mg
Sodium R-lipoate 50 mg
Other ingredients: Acacia gum, rice flour.
Bioperine® is a registered trademark and proprietary product of Sabinsa Corporation.
Directions for use
Take two capsules twice a day, or as advised by your therapist.
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References
  1. Croom E. Metabolism of xenobiotics of human environments. Prog Mol Biol Transl Sci. 2012;112:31-88. doi: 10.1016/B978-0-12-415813-9.00003-9. PMID: 22974737.
  2. Palmieri B, Corazzari V, Panariello Brasile DG, Sangiovanni V, VadalÀ M. Hepatic steatosis integrated approach: nutritional guidelines and joined nu-traceutical administration. Minerva Gastroenterol Dietol. 2020 Dec;66(4):307-320. doi: 10.23736/S1121-421X.20.02738-5. PMID: 33443240.
  3. He Z, Li X, Yang H, et al. Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Front Nutr. 2021;8:745609. Published 2021 Sep 14. doi:10.3389/fnut.2021.745609
  4. Pizzorno J. Glutathione! Integr Med (Encinitas). 2014 Feb;13(1):8-12. PMID: 26770075; PMCID: PMC4684116.
  5. Abdel-Nabi R, Milakofsky L, Hofford JM, Hare TA, Vogel WH. Effect of ethanol on amino acids and related compounds in rat plasma, heart, aorta, bronchus, and pancreas. Alcohol. 1996 Mar-Apr;13(2):171-4. doi: 10.1016/0741-8329(95)02031-4. PMID: 8814652.
  6. Penetar DM, Toto LH, Lee DY, Lukas SE. A single dose of kudzu extract re-duces alcohol consumption in a binge drinking paradigm. Drug Alcohol De-pend. 2015;153:194-200. doi:10.1016/j.drugalcdep.2015.05.025
  7. Yang G, Ge S, Singh R, Basu S, Shatzer K, Zen M, Liu J, Tu Y, Zhang C, Wei J, Shi J, Zhu L, Liu Z, Wang Y, Gao S, Hu M. Glucuronidation: driving factors and their impact on glucuronide disposition. Drug Metab Rev. 2017 May;49(2):105-138. doi: 10.1080/03602532.2017.1293682. Epub 2017 May 22. PMID: 28266877; PMCID: PMC7660525.
  8. Feng C, Bai K, Wang A, et al. Effects of dimethylglycine sodium salt supple-mentation on growth performance, hepatic antioxidant capacity, and mito-chondria-related gene expression in weanling piglets born with low birth weight1. J Anim Sci. 2018;96(9):3791-3803. doi:10.1093/jas/sky233
  9. Farzaei MH, Zobeiri M, Parvizi F, et al. Curcumin in Liver Diseases: A Syste-matic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective. Nutrients. 2018;10(7):855. Published 2018 Jul 1. doi:10.3390/nu10070855
  10. Zhao L, Mehmood A, Soliman MM, et al. Protective Effects of Ellagic Acid Against Alcoholic Liver Disease in Mice. Front Nutr. 2021;8:744520. Pu-blished 2021 Sep 14. doi:10.3389/fnut.2021.744520
  11. Rahimlou M, Yari Z, Hekmatdoost A, Alavian SM, Keshavarz SA. Gin-ger Supplementation in Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Hepat Mon. 2016;16(1):e34897. Published 2016 Jan 23. doi:10.5812/hepatmon.34897
  12. Gillessen A, Schmidt HH. Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Adv Ther. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y
  13. Nguyen H, Gupta V. Alpha-Lipoic Acid. [Updated 2021 Nov 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK564301/
  14. Björnsson ES. Drug-induced liver injury due to antibiotics. Scand J Gastroenterol. 2017 Jun-Jul;52(6-7):617-623. doi: 10.1080/00365521.2017.1291719. Epub 2017 Feb 20. PMID: 28276834.
  15. Osna NA, Donohue TM Jr, Kharbanda KK. Alcoholic Liver Disease: Pa-thogenesis and Current Management. Alcohol Res. 2017;38(2):147-161.
  16. Kaneko R, Ohishi C, Kim M, Shiina M, Kusayanagi S, Ogawa M, Mu-nakata K, Mizuno K, Sato Y. Two cases of food additive-induced severe liver damage associated with positive results on lymphocyte stimulation test and for antinuclear antibodies. Clin J Gastroenterol. 2012 Aug;5(4):268-74. doi: 10.1007/s12328-012-0312-7. Epub 2012 Jun 4. PMID: 26182392.
  17. Guan YS, He Q. Plants Consumption and Liver Health. Evid Based Complement Alternat Med. 2015;2015:824185. doi:10.1155/2015/824185
  18. Popkin BM, D'Anci KE, Rosenberg IH. Water, hydration, and health. Nutr Rev. 2010;68(8):439-458. doi:10.1111/j.1753-4887.2010.00304.x
  19. Bahrami G, Malekshahi H, Miraghaee S, Madani H, Babaei A, Moham-madi B, Hatami R. Protective and Therapeutic Effects of Aloe Vera Gel on Ul-cerative Colitis Induced by Acetic Acid in Rats. Clin Nutr Res. 2020 Jul 30;9(3):223-234. doi: 10.7762/cnr.2020.9.3.223. PMID: 32789152; PMCID: PMC7402976.
  20. Vojdani A. Lectins, agglutinins, and their roles in autoimmune reactivi-ties. Altern Ther Health Med. 2015;21 Suppl 1:46-51. PMID: 25599185.

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